A WOMAN was trapped in the wreckage of her car after running off the road and striking a large tree on Sunday.
The driver, aged in her mid 60s, was treated by intensive care paramedics while rescue crews worked to free her. The collision occurred in thick fog shortly before 8.30am.
The car left the incorrect side of the Loddon Valley Highway, veered across the sidecut and struck the tree head-on.
The driver was stabilised at the scene and conveyed to Serpentine football oval, where she was transferred to an ambulance helicopter and airlifted to the Royal Melbourne Hospital.
An Ambulance Victoria spokesman said the woman suffered arm, chest and facial injuries, and was taken from the scene in a serious but stable condition.
Police are still working to determine the cause of the crash, with a number of factors potentially involved. Thick fog and fatigue are factors being considered as possible causes.